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68Ga-DOTA-NT

Development stage: Unknown
Lead developer: MedKoo Biosciences
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptide-Drug Conjugates → Peptide Conjugates → Peptides
Administration: Intravenous

Overview

68Ga-DOTA-NT is a radiopharmaceutical compound consisting of the neurotensin analog peptide DOTA-NT (DOTA-conjugated neurotensin) labeled with the positron-emitting radionuclide gallium-68. It is designed for use in positron emission tomography (PET) imaging to target and visualize tumors that overexpress the neurotensin receptor subtype 1 (NTSR1). The mechanism of action involves specific binding of the radiolabeled peptide to NTSR1 on tumor cells, enabling high-sensitivity detection and localization of NTSR1-positive malignancies, such as certain pancreatic adenocarcinomas. This agent has demonstrated higher PET detection rates for some cancers compared to standard tracers like 18F-FDG[2]. The compound is primarily used in research and investigational settings.

Other names: DOTA-NT-20.3DOTA-NT20.3DOTA-NT 20.3

Targets

NTR1 (Nitroreductase-1)

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