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68Ga-EV203
- Development stage
- Unknown
- Lead developer
- Zhejiang Province Cancer Hospital
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
68Ga-EV203 is an investigational radiopharmaceutical PET tracer developed for the imaging of CD138-positive hematologic malignancies. It consists of the humanized monoclonal antibody EV203, which specifically targets Syndecan-1 (CD138), conjugated to the positron-emitting isotope Gallium-68 (68Ga). CD138 is a cell surface proteoglycan that is highly and consistently expressed on malignant plasma cells in multiple myeloma, as well as in certain cases of non-Hodgkin lymphoma and acute myeloid leukemia. By binding to CD138, 68Ga-EV203 allows for the non-invasive visualization and quantification of tumor burden and CD138 expression levels using PET/CT imaging. This tracer is primarily being evaluated for its safety, biodistribution, and diagnostic performance in patients with multiple myeloma and other CD138-expressing hematologic cancers to aid in staging and treatment planning.
- Other names
- 68Ga-labeled EV203Gallium-68 EV203Gallium68 EV203Gallium 68 EV203
02
Targets
SDC1 (Syndecan-1)
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