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68Ga FAPI-46

Development stage: Phase 2
Lead developer: SOFIE
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

Gallium Ga 68 FAPI‑46 is a radiopharmaceutical diagnostic agent composed of the quinoline-based fibroblast activation protein inhibitor (FAPi)-46, labeled with the radioisotope gallium‑68. It acts as a highly specific positron emission tomography (PET) imaging tracer targeting fibroblast activation protein (FAP), which is overexpressed in cancer-associated fibroblasts and various tumor types. Upon administration, it binds to FAP-expressing cells, enabling their detection via PET/CT imaging. This agent is under investigation for its ability to improve tumor visualization and staging across multiple cancers and has also shown potential utility in inflammatory diseases[2][3][7][10].

Brand names: [68Ga]FAPI-46
Other names: 68-Ga FAPI 46(68Ga)Ga-Fapi-46

Targets

FAP (Fibroblast activation protein alpha)

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