Drug intelligence / Profile preview

68Ga-FAPI-XT117

Development stage: Phase 1
Lead developer: Sinotau Pharmaceutical Group
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

68Ga-FAPI-XT117 is a novel radiopharmaceutical diagnostic imaging agent developed for positron emission tomography (PET/CT). It consists of the XT117 ligand, which specifically targets **fibroblast activation protein (FAP)**, labeled with the radioisotope **gallium-68 (68Ga)**. FAP is a cell-surface glycoprotein highly expressed by cancer-associated fibroblasts (CAFs) within the tumor microenvironment of various malignant solid tumors, while showing low expression in normal tissues. Developed by **Sinotau Pharmaceutical Group** in collaboration with the **Chinese PLA General Hospital**, this tracer is being evaluated for its safety and diagnostic efficacy, particularly in patients with sarcomas and gastrointestinal cancers. It aims to provide high-contrast imaging and potentially superior lesion detection compared to conventional 18F-FDG PET/CT, especially in tumors with high stromal content.

Other names: 68Ga/64Cu-FAPI-XT11764Cu-FAPI-XT117

Targets

FAP (Fibroblast activation protein alpha)

Beyond the preview

Go deeper on 68Ga-FAPI-XT117.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on 68Ga-FAPI-XT117.

Explore the full profile