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68Ga-FC335
- Development stage
- Unknown
- Lead developer
- FindCure Biosciences
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**68Ga-FC335** is a gallium-68 labeled radionuclide drug conjugate (RDC) developed by FindCure Biosciences (also known as Findcure). It is designed as a diagnostic radiopharmaceutical targeting fibroblast activation protein alpha (FAPα), which is highly expressed in the tumor microenvironment of various solid tumors. By binding specifically to FAPα, 68Ga-FC335 serves as a positron emission tomography (PET) imaging tracer to visualize and diagnose FAPα-positive solid tumors, including pancreatic, lung, esophageal, and gastric cancers. The agent is currently in Phase 1 clinical development, with completed investigator-initiated trials (IITs) demonstrating its potential as a companion diagnostic alongside its therapeutic lutetium-177 labeled counterpart, 177Lu-FC335.
- Other names
- [68Ga]Ga-FC33568Ga-labeled FC335gallium Ga 68 FC335
02
Targets
FAP (Fibroblast activation protein alpha)
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