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68Ga-folate-KR
- Development stage
- Unknown
- Lead developer
- Peking University Third Hospital
- Modality
- Beta Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Alpha Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**68Ga-folate-KR** is a heterodimeric PET radiotracer developed for dual-receptor imaging in cancer, specifically designed to target both **folate receptor α (FRα)** and **human epidermal growth factor receptor 2 (HER2)**. This compound is labeled with gallium-68 and consists of a folate moiety and a HER2-targeting KR peptide, connected via a linker that allows simultaneous binding to both receptors. In vitro and in vivo studies demonstrated that 68Ga-folate-KR binds specifically to FRα and HER2, showing enhanced tumor uptake and improved tumor-to-background contrast compared to monomeric tracers. It is intended for non-invasive PET detection and characterization of tumors (such as ovarian cancer) that overexpress either or both FRα and HER2.
- Other names
- 68Ga-folate-KR
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)1C metabolism (One-carbon metabolism)
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