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68Ga-Glu-urea-Lys-HBED-CC-AlexaFluor488
- Development stage
- Preclinical
- Lead developer
- German Cancer Research Center
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Light/Condition-Responsive Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
**68Ga-Glu-urea-Lys-HBED-CC-AlexaFluor488** is a preclinical dual-modality prostate-specific membrane antigen-targeted imaging probe derived from the PSMA-11 scaffold. It combines a gallium-68 PET radiolabel with the Alexa Fluor 488 fluorescent dye, enabling preoperative PET localization and potential intraoperative fluorescence visualization of PSMA-expressing prostate cancer tissue. The Glu-urea-Lys pharmacophore binds and is internalized through PSMA, while HBED-CC chelates gallium-68. In mouse tumor models, the probe showed PSMA-specific tumor uptake comparable to 68Ga-PSMA-11; its reported evaluation was preclinical.
02
Targets
PSMA (Prostate-specific membrane antigen)
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