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68Ga-GSI

Development stage: Preclinical
Lead developer: Fudan University Shanghai Cancer Center
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals
Administration: Intravenous

Overview

68Ga-GSI is a radiopharmaceutical designed as a positron emission tomography/computed tomography (PET/CT) probe. It targets Granzyme B (GzmB), a protein involved in the immune response. This diagnostic agent is being developed to evaluate early tumor responses to immunotherapy, particularly immune checkpoint inhibitors, by reflecting the immune activation state within tumors. It is currently under clinical investigation for various cancers, including gastric cancer, esophageal cancer, and non-small cell lung cancer.

Targets

GZMB (Granzyme B)

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