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68Ga-JH12

Development stage: Phase 1
Lead developer: Bivision Pharmaceuticals
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

68Ga-JH12 is a novel radiopharmaceutical designed for positron emission tomography (PET) imaging. It specifically targets the C-X-C motif chemokine receptor 4 (CXCR4), which is highly expressed in various malignant tumors. By binding to CXCR4, 68Ga-JH12 enables non-invasive visualization of tumors with high CXCR4 expression, supporting cancer diagnosis and potentially patient stratification for targeted therapies. Preclinical studies have demonstrated its high stability, tumor-specific accumulation, strong binding affinity, safety, and selectivity. The agent is currently being evaluated in phase 1 clinical trials to assess its safety profile, biodistribution, and radiation dosimetry in patients with different types of solid tumors[1][2].

Other names: [68Ga]Ga-JH12

Targets

CXCR4 (C-X-C motif chemokine receptor 4)

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