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68Ga-JH120061
- Development stage
- Unknown
- Lead developer
- Bivision Pharmaceuticals
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Peptides
- Administration
- Intravenous
01
Overview
68Ga-JH120061 is a novel gallium-68 labeled cyclic peptide radiopharmaceutical targeting C-X-C motif chemokine receptor 4 (CXCR4). Developed by Bivision in collaboration with researchers at Fujian Medical University, it is designed as a diagnostic imaging agent for positron emission tomography/computed tomography (PET/CT) to detect CXCR4-positive tumors. In clinical and preclinical studies, 68Ga-JH120061 has demonstrated high binding affinity, cellular uptake, and prolonged retention in CXCR4-expressing tumors, showing particular diagnostic efficacy in clear-cell renal cell carcinoma (ccRCC) and multiple myeloma compared to established tracers like 68Ga-Pentixafor.
- Other names
- [68Ga]Ga-JH120061
02
Targets
CXCR4 (C-X-C motif chemokine receptor 4)
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