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68Ga-MM-BC1

Development stage
Phase 2
Lead developer
Peking University First Hospital
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptide-Drug Conjugates → Peptide Conjugates → Peptides
Administration
Intravenous
01

Overview

68Ga-MM-BC1 is a PET imaging radiopharmaceutical developed for the diagnosis of Multiple Myeloma (MM). It consists of a peptide or nanobody targeting BCMA (B-cell maturation antigen) that has been radiolabeled with the positron-emitting isotope gallium-68. This novel molecular probe was developed through computer-aided design to overcome limitations of traditional full-length antibody probes, which suffer from delayed tumor uptake peaks and low target-to-background ratios. The physical half-life of gallium-68 is approximately 68 minutes, after which it transforms to stable zinc-68.

02

Targets

BCMA (B-cell maturation antigen)

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