Drug intelligence / Profile preview

68Ga-NODAGA-SNA006

Development stage
Phase 2
Lead developer
SmartNuclide
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics, Peptides
Administration
Intravenous
01

Overview

68Ga-NODAGA-SNA006 is a radiopharmaceutical compound used for positron emission tomography (PET) imaging to quantify CD8 expression in vivo. It consists of a nanobody (SNA006) site-specifically conjugated with the chelator NODAGA and radiolabeled with gallium-68. The drug binds specifically to CD8+ T cells, enabling noninvasive visualization and quantification of tumor-infiltrating CD8+ T lymphocytes in patients with solid tumors. This allows dynamic tracking of immune responses during cancer immunotherapy and may help guide individualized treatment strategies. Clinical studies have shown that it is well tolerated, exhibits rapid clearance from circulation, and provides high-quality imaging correlating with histological CD8 expression[1][2][3][4][5].

Other names
[68Ga]Ga-NODAGA-SNA006
02

Targets

CD8A (CD8 alpha/beta Coreceptor)

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