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68Ga-NODAGA-SNA009

Development stage: Phase 1
Lead developer: SmartNuclide
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

68Ga-NODAGA-SNA009 is a nanobody-based PET imaging tracer developed by Suzhou SmartNuclide Biopharmaceutical for the detection of colorectal cancer. The agent comprises a nanobody (SNA009) that specifically targets Carcinoembryonic Antigen (CEA), also known as CEACAM5, a protein frequently overexpressed on the surface of colorectal cancer cells. This nanobody is conjugated to the chelator NODAGA and radiolabeled with the positron-emitting isotope Gallium-68 (68Ga). Due to the small size of the nanobody (VHH), the tracer exhibits rapid systemic clearance and high tumor penetration, enabling high-contrast PET/CT imaging of CEA-positive lesions shortly after administration. It is currently in Phase 1 clinical development for safety, biodistribution, and radiation dosimetry in patients with colorectal cancer.

Other names: [68Ga]Ga-NODAGA-SNA009

Targets

GPA33 (Glycoprotein A33)

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