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68Ga-NODAGA-SNA014

Development stage: Unknown
Lead developer: SmartNuclide
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

68Ga-NODAGA-SNA014 is an investigational radiopharmaceutical PET imaging agent developed by SmartNuclide Biopharma. It consists of a Claudin 18.2 (CLDN18.2)-targeting single-domain antibody (nanobody), SNA014, conjugated to a NODAGA chelator and radiolabeled with the positron-emitting isotope Gallium-68. CLDN18.2 is a tight-junction protein frequently overexpressed in gastrointestinal malignancies, including gastric and pancreatic cancers. The agent is designed for noninvasive quantification of CLDN18.2 expression via PET/CT imaging, serving as a companion diagnostic to identify patients likely to benefit from CLDN18.2-targeted therapies.

Other names: [68Ga]Ga-NODAGA-SNA01468Ga-labeled nanobody

Targets

Claudin 18.2

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