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68Ga-NOTA-G3-NGR2

Development stage: Preclinical
Lead developer: Texas A&M University
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

68Ga-NOTA-G3-NGR2 is a radiopharmaceutical agent designed for positron emission tomography (PET) imaging. It consists of a gallium-68 radioisotope chelated by NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid), conjugated to a G3 trimeric peptide containing the asparagine-glycine-arginine (NGR) motif. The NGR sequence targets aminopeptidase N (CD13), which is overexpressed in tumor neovasculature and certain cancer cells. This enables selective imaging of tumors and their metastases by PET scanning. Preclinical studies have shown that 68Ga-NOTA-G3-NGR2 demonstrates favorable tumor uptake and high tumor-to-background ratios in models such as fibrosarcoma and gastric cancer with liver metastasis[3][7]. Its primary use is investigational for the detection and evaluation of malignant lesions.

Brand names: 68Ga-NOTA-G3-NGR2
Other names: 68Ga-NOTA-G3-NGR2

Targets

ANPEP (Aminopeptidase N)

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