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68Ga-NOTA-MAL-MZHER2

Development stage: Unknown
Lead developer: Xijing Hospital
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

68Ga-NOTA-MAL-MZHER2 is a radiopharmaceutical PET imaging agent developed by Xijing Hospital for the non-invasive detection of human epidermal growth factor receptor 2 (HER2) expression in tumors. It consists of a small engineered protein scaffold (affibody molecule), approximately 7 kDa in size, labeled with the positron-emitting radioisotope Gallium-68 via a NOTA-MAL chelator. By targeting the HER2 receptor with high affinity and specificity, the agent allows for the visualization of HER2-positive lesions in patients with breast or gastric cancer, potentially guiding the selection of HER2-targeted therapies. Its small size facilitates rapid blood clearance and high-contrast imaging shortly after injection.

Other names: 68Ga labeled HER2 Affibody68Ga-HER2 affibody68Ga labeled HER2 Affibody-Xijing Hospital

Targets

ERBB2 (Erb-b2 receptor tyrosine kinase 2)

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