68Ga-NOTA-PTDGd

68Ga-NOTA-PTDGd is a radiolabeled peptide-based PET imaging agent developed for the non-invasive assessment of galectin-1 (Gal-1) expression, which serves as a surrogate marker for tumor hypoxia. The tracer consists of the PTDGd peptide, which exhibits high affinity for Gal-1, conjugated to the chelator NOTA and labeled with the positron-emitting isotope Gallium-68. Galectin-1 is a carbohydrate-binding protein that is significantly upregulated in the hypoxic regions of various solid tumors and plays a critical role in tumor angiogenesis, immunosuppression, and metastasis. By targeting Gal-1, 68Ga-NOTA-PTDGd allows for the visualization and quantification of hypoxic tumor microenvironments, potentially aiding in tumor staging, treatment planning, and monitoring response to therapies that target hypoxia or Gal-1. The development is primarily associated with researchers at Peking University.

Other names

[68Ga]Ga-NOTA-PTDGdGa-68 NOTA-PTDGdGa68 NOTA-PTDGdGa 68 NOTA-PTDGd