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68Ga-NOTA-RM26

Development stage: Phase 1
Lead developer: Peking Union Medical College Hospital
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptide-Drug Conjugates → Peptide Conjugates → Peptides
Administration: Intravenous

Overview

68Ga-NOTA-RM26 is a radiopharmaceutical diagnostic agent composed of RM26, a synthetic bombesin analogue and antagonist of the gastrin-releasing peptide receptor (GRPR), conjugated via the macrocyclic chelator NOTA (1,4,7-triazacyclononane-N,N',N''-triacetic acid) to the positron-emitting radionuclide gallium-68. It is designed for use in positron emission tomography/computed tomography (PET/CT) imaging to non-invasively detect and characterize tumors that overexpress GRPR. The primary mechanism involves selective binding to GRPR on tumor cells, enabling visualization of receptor expression in vivo. This agent has been investigated primarily for imaging high-grade gliomas and prostate cancer, with studies demonstrating its safety and efficacy in distinguishing tumor grades and guiding biopsies[1][3][6][8][9].

Other names: gallium Ga 68-NOTA-RM26

Targets

GRPR (Gastrin-releasing peptide receptor)

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