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68Ga-NTBP
- Development stage
- Preclinical
- Lead developer
- Nanjing First Hospital
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Cyclic Peptides → Modified Peptides → Peptides
- Administration
- Intravenous
01
Overview
68Ga-NTBP is a newly synthesized gallium-68 (68Ga) radiolabeled bicyclic peptide targeting Nectin-4 (Poliovirus receptor-related protein 4). It is developed as a positron emission tomography (PET) imaging tracer for the non-invasive quantification of Nectin-4 expression in tumors, particularly urothelial carcinoma. By binding specifically to Nectin-4, 68Ga-NTBP allows for patient stratification and screening for Nectin-4-targeted therapies, such as antibody-drug conjugates (ADCs) like enfortumab vedotin. Preclinical evaluations demonstrate high radiochemical purity, stability, rapid renal excretion, and a strong positive correlation between tumor uptake and Nectin-4 expression levels.
- Other names
- 68Ga-labeled Nectin-4 targeted bicyclic peptide68Ga-labeled bicyclic peptide targeting Nectin-4
02
Targets
PVRL4 (Nectin cell adhesion molecule 4)
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