Drug intelligence / Profile preview

68Ga-PL282

Development stage
Preclinical
Lead developer
Xuanwu Hospital
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Peptides
Administration
Intravenous
01

Overview

68Ga-PL282 is an artificial intelligence (AI)-designed peptide radiotracer labeled with gallium-68 (68Ga) for positron emission tomography (PET) imaging of programmed death-ligand 1 (PD-L1) expression. Developed by Xuanwu Hospital of Capital Medical University, the tracer is designed to mimic the binding characteristics of known PD-L1 binders. In preclinical studies, 68Ga-PL282 demonstrated high affinity and specificity for PD-L1, rapid cellular uptake, and a favorable pharmacokinetic profile with rapid clearance from non-target organs, enabling non-invasive, quantitative assessment of PD-L1 expression and visualization of intra-tumoral heterogeneity.

Other names
68Ga-P282[68Ga]Ga-PL282
02

Targets

CD274 (Programmed cell death protein 1 ligand 1)

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