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68Ga-PSFA

Development stage: Unknown
Lead developer: First Affiliated Hospital of Chongqing Medical University
Modality: Alpha Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

68Ga-PSFA is a novel dual-targeting radiopharmaceutical used for positron emission tomography (PET) imaging. This innovative diagnostic radiopharmaceutical is designed for imaging PSMA/FAP positive diseases, particularly in oncology applications. The dual-target nature of 68Ga-PSFA enhances its detection capabilities compared to single-target agents like 68Ga-PSMA-11. Clinical studies have shown that 68Ga-PSFA-01 PET/CT demonstrated higher detection rates and visual assessment efficacy compared to 68Ga-PSMA-11 PET/CT in prostate cancer patients.

Targets

FAP (Fibroblast activation protein alpha)PSMA (Prostate-specific membrane antigen)

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