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68Ga-R14014
- Development stage
- Unknown
- Lead developer
- First Affiliated Hospital of Xi'an Jiaotong University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous
01
Overview
68Ga-R14014 is a diagnostic radiopharmaceutical developed by The First Affiliated Hospital of Xi'an Jiaotong University for the positron emission tomography (PET) imaging of advanced solid tumors. The agent consists of a targeting ligand, R14014, labeled with the positron-emitting radioisotope gallium-68 (^68Ga). R14014 is designed to specifically bind to **integrin alpha-V beta-6** (αvβ6), a cell-surface receptor that is highly upregulated in several epithelial-derived malignancies, including pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), and head and neck squamous cell carcinoma (HNSCC), while showing minimal expression in healthy tissues. By targeting this receptor, 68Ga-R14014 allows for the non-invasive visualization of tumor lesions and the assessment of target density. It is typically developed as part of a theranostic pair alongside the therapeutic agent 177Lu-R14014, enabling a personalized approach to identifying and treating αvβ6-positive cancers.
- Other names
- [68Ga]Ga-R14014
02
Targets
αVβ3 (Integrin αVβ3)ITGA5:ITGB1 (Integrin α5β1)αVβ8 (Integrin alpha V beta 8)αVβ6 (Integrin αVβ6)
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