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68Ga-THP-APN09

Development stage: Preclinical
Lead developer: King's College London
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

68Ga-THP-APN09 is a radiopharmaceutical candidate designed for positron emission tomography (PET) imaging of Aminopeptidase N (APN/CD13) expression. It consists of the radioisotope Gallium-68 (68Ga) chelated by a tris(hydroxypyridinone) (THP) ligand, which is conjugated to the APN09 peptide. APN09 is a cyclic peptide ligand that specifically binds to CD13, a zinc-dependent metalloproteinase overexpressed on the surface of various tumor cells and neovascular endothelial cells during angiogenesis. The use of the THP chelator allows for rapid, high-affinity radiolabeling at room temperature and near-neutral pH, facilitating simplified "shake-and-shoot" radiopharmacy applications. This tracer is primarily investigated for its potential in detecting CD13-positive tumors and monitoring tumor-associated angiogenesis in oncology.

Other names: Gallium (68Ga) THP-APN0968Ga-labeled THP-APN09

Targets

CD274 (Programmed cell death protein 1 ligand 1)

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