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68Ga-TRD4425

Development stage: Unknown
Lead developer: Guangdong Second Provincial General Hospital
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

68Ga-TRD4425 is a gallium-68 labeled radiopharmaceutical designed for positron emission tomography (PET) imaging of solid tumors expressing the gastrin-releasing peptide receptor (GRPR). Developed by the Guangdong Second Provincial General Hospital, it serves as a diagnostic companion to the therapeutic agent 177Lu-TRD4425 in a theranostic approach. GRPR is frequently overexpressed in various cancers, including estrogen receptor-positive breast cancer and hormone-sensitive prostate cancer. The tracer allows for the non-invasive assessment of GRPR expression, biodistribution, and lesion detection, facilitating patient selection for GRPR-targeted radioligand therapy.

Other names: [68Ga]Ga-TRD4425

Targets

GRPR (Gastrin-releasing peptide receptor)

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