6b

6b is a novel indole-acrylamide derivative synthesized as part of a series of xenobiotics designed to target cyclooxygenase (COX) pathways. It functions as a selective inhibitor of cyclooxygenase-2 (COX-2) and has demonstrated significant antiproliferative and cytotoxic effects in preclinical cancer models. Specifically, 6b has shown potent activity against breast cancer (MCF-7) and melanoma (B16F1) cell lines, with IC50 values ranging from 4.75 to 15.4 µM. The compound was developed to explore the correlation between COX-2 inhibition and anticancer efficacy, positioning it as a potential candidate for further investigation in the treatment of cancer and inflammatory conditions.