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6bK
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral, Intperitoneal
01
Overview
6bK is a potent, selective, and physiologically active small-molecule macrocyclic inhibitor of insulin-degrading enzyme (IDE) with an IC50 of approximately 50 nM. Discovered by researchers at Harvard University through the screening of a DNA-templated macrocycle library, 6bK binds to an exosite of IDE rather than its catalytic active site, achieving over 1,000-fold selectivity over other metalloproteases. In animal models, 6bK regulates the levels of insulin, glucagon, and amylin, improving oral glucose tolerance and delaying gastric emptying. It is widely used as a research tool to study the physiological roles of IDE in type 2 diabetes, glucose homeostasis, and insulin clearance.
- Other names
- (3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide6bK formate6bK TFAIDE-IN-1IDE-IN1IDE-IN 1
02
Targets
IDE (Insulin-degrading enzyme)
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