7-deazaguanine

**7-Deazaguanine** is a synthetic analog of guanine in which the nitrogen at position seven of the purine ring is replaced by a carbon atom. It belongs to the class of pyrrolopyrimidines and has been studied primarily as an experimental compound. In biological systems—particularly in certain bacteria and bacteriophages—derivatives of 7-deazaguanine are incorporated into DNA or RNA as modified nucleobases. These modifications can play roles in protecting genetic material from restriction enzymes (antirestriction systems), serving as epigenetic marks, or providing resistance to environmental stressors such as radiation. Recent research has identified that some derivatives act through diverse mechanisms including inhibition of protein kinases (such as DYRK1A) and interference with cellular processes associated with adenine nucleosides. For example, some deazapurines related to this scaffold have shown cytotoxicity via protein kinase C inhibition or cyclin-dependent kinase inhibition; however, these effects are more established for closely related compounds rather than for unmodified 7-deazaguanine itself. In laboratory settings, it is used mainly for biochemical research purposes—including studies on DNA modification and enzyme substrate specificity—and not approved for clinical use in humans.[1][4][8]

Other names

2-amino-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-ol2-amino-4-hydroxypyrrolo[2,3-d]pyrimidine2-amino-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-oneUNII-GPL8T5ZO3MUNII-GPL-8T5ZO3MUNII-GPL 8T5ZO3MGPL8T5ZO3MGPL-8T5ZO3MGPL 8T5ZO3M2-amino-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one