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7-GLG-PT liposome

Development stage: Preclinical
Lead developer: Kurashiki University of Science and the Arts
Modality: Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
Administration: Intravenous

Overview

7-GLG-PT liposome is a liposomal formulation of 7-alpha-glucosyloxyacetylpaclitaxel (7-GLG-PT), a water-soluble glycosylated prodrug of the microtubule-stabilizing chemotherapeutic agent paclitaxel. Developed by researchers in Japan, including Kurashiki University of Science and the Arts, Okayama University, and Ensuiko Sugar Refining, 7-GLG-PT was designed to overcome the poor water solubility of paclitaxel by coupling glucose at the 7-OH position via a glycolic acid linker. Encapsulation of 7-GLG-PT into liposomes is highly efficient compared to paclitaxel. The liposomal formulation serves as an intermediate for the preparation of HER2-targeted immunoliposomes (GLG-PT-IL) by conjugating trastuzumab to the liposome surface, but also exhibits direct cytotoxic activity against cancer cells by releasing the paclitaxel derivative to inhibit microtubule depolymerization.

Other names: 7-alpha-glucosyloxyacetylpaclitaxel liposome7-GLG-PT liposomesliposomal 7-alpha-glucosyloxyacetylpaclitaxelliposomal7-alpha-glucosyloxyacetylpaclitaxelliposomal-7-alpha-glucosyloxyacetylpaclitaxelliposomal 7-GLG-PTliposomal7-GLG-PTliposomal-7-GLG-PT

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