7-glucosyloxyacetylpaclitaxel

7-GLG-PT (7-glucosyloxyacetylpaclitaxel) is a water-soluble, glycosylated prodrug of the microtubule-stabilizing chemotherapeutic agent paclitaxel. Developed by researchers at Kurashiki University of Science and the Arts, Okayama University, and Ensuiko Sugar Refining, the compound was designed to overcome the extreme hydrophobicity of paclitaxel, which typically requires toxic formulation vehicles like Cremophor EL. By coupling a glucose moiety at the 7-OH position of paclitaxel via an acetyl linker, 7-GLG-PT exhibits significantly enhanced water solubility while retaining the ability to stabilize tubulin polymerization. This hydrophilic profile allows for highly efficient encapsulation into the aqueous core of liposomes. In preclinical studies, 7-GLG-PT has been formulated into HER2-targeted immunoliposomes (conjugated with trastuzumab) to selectively deliver the drug to HER2-overexpressing breast and colorectal cancer cells, demonstrating potent antitumor efficacy and reduced systemic toxicity in vivo.

Other names

7-alpha-glucosyloxyacetylpaclitaxel7-glucosyloxyacetylpaclitaxelgPTXglycosylated paclitaxel