Drug intelligence / Profile preview

7-hydroxymitragynine

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

7-hydroxymitragynine (7-OH) is a terpenoid indole alkaloid and a potent active metabolite of mitragynine, the primary alkaloid found in the kratom plant (*Mitragyna speciosa*). It acts as a potent agonist at the mu-opioid receptor (MOR) and is estimated to be significantly more potent than morphine. While naturally occurring in trace amounts in kratom leaves, it is often produced semi-synthetically from mitragynine for use in concentrated products such as tablets and gummies. 7-OH is primarily used for its analgesic properties but is associated with a high potential for abuse, addiction, and respiratory depression. Currently, it has no FDA-approved medical uses and is subject to significant regulatory scrutiny, with recommendations for Schedule I classification due to safety concerns.

Brand names
7OHMZPress'dEDP7-Labs
Other names
7-OH7-OHM7-hydroxymitragynine
02

Targets

MOR (Mu opioid receptor)DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)

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