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7-nitroindazole
- Development stage
- Preclinical
- Lead developer
- Beyond Air
- Modality
- Small Molecules
- Administration
- Intraperitoneal (in Animal Studies)
01
Overview
**7-Nitroindazole** is a small molecule experimental drug that acts as a selective inhibitor of neuronal nitric oxide synthase (nNOS). It is primarily used in research to study the role of nitric oxide (NO) in the brain and has demonstrated antinociceptive (pain-reducing) and neuroprotective effects in animal models. Mechanistically, it inhibits various isoforms of nitric oxide synthase, with selectivity for the neuronal form over endothelial or inducible forms. It has been investigated for its potential use in neurological diseases such as Parkinson's disease and for its effects on cerebral blood flow regulation[1][2][4][5][9]. The compound is not approved for clinical use and remains an experimental tool compound.
- Other names
- 7-nitroindazole7-NInitroindazole7-nitro-1H-indazoleindazole, 7-nitro-2H-indazole, 7-nitro-7-Nitroisoindazole
02
Targets
NOS3 (eNOS)NOS1 (nNOS)NOS2 (Nitric Oxide Synthase 2)
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