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7-thionicotinamide-adenine-dinucleotide phosphate
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
7-thionicotinamide-adenine-dinucleotide phosphate is a synthetic analog of nicotinamide adenine dinucleotide phosphate (NADP), in which the nicotinamide moiety is replaced by thionicotinamide. It belongs to the class of (5'->5')-dinucleotides and has a molecular formula of C21H28N7O16P3S. This compound is primarily used as an experimental biochemical tool rather than as a therapeutic drug. It can act as an alternative cofactor in enzymatic reactions that normally utilize NADP(H), and it has been studied for its ability to block NAADP-induced calcium release[1][2][8]. Its mechanism involves mimicking or interfering with natural NAD(P)H-dependent processes; for example, it can be used to probe redox biochemistry or modulate calcium signaling pathways.
- Other names
- 7-thionicotinamide-adenine-dinucleotide phosphateS-NADPThio-NADPThionicotinamide adenine dinucleotide phosphate sodium salt
02
Targets
TPC (Two-pore channel)
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