70-1XX CAR T cells

70-1XX CAR T cells are an experimental chimeric antigen receptor (CAR) T-cell therapy designed to target the CD70 antigen, which is frequently expressed in renal cell carcinoma and other malignancies. This construct utilizes the "1XX" signaling architecture, a modified version of the CD3ζ endodomain where two of the three immunoreceptor tyrosine-based activation motifs (ITAMs) are inactivated. Developed by the Michel Sadelain laboratory, the 1XX design is intended to calibrate T-cell activation to prevent overstimulation and exhaustion, thereby enhancing the long-term functional persistence and anti-tumor efficacy of the CAR T cells. In preclinical studies, 70-1XX CAR T cells have been evaluated for their ability to clear tumors in renal cell carcinoma models, particularly in contexts where antigen density is low or downregulated.

Other names

CD70-1XX CAR T cellsCD-70-1XX CAR T cellsCD 70-1XX CAR T cells