740 Y-P

**740 Y-P is a synthetic cell-permeable phosphopeptide that acts as a potent activator of phosphoinositide 3-kinase (PI3K).** It is designed to mimic the phosphorylated tyrosine motif found in the platelet-derived growth factor receptor (PDGFR), specifically at position Tyr-740. The peptide sequence includes an Antennapedia protein transduction domain to facilitate cellular uptake. Mechanistically, it binds to the SH2 domains of the p85 regulatory subunit of PI3K and stimulates PI3K activity both in vitro and in vivo. This activation leads to downstream signaling through pathways such as PI3K/Akt/mTOR and can stimulate mitogenesis even at low concentrations[1][2][5][9]. In research models, it has been shown to increase phosphorylation of AKT and PI3K and reduce reactive oxygen species levels in neuronal tissue[5]. Its primary use is as a biochemical tool for studying signal transduction related to cell proliferation, survival, autophagy modulation, apoptosis inhibition, and neuroprotection. It is not approved for clinical or therapeutic use; all applications are limited strictly to laboratory research.

Other names

PDGFR 740Y-PPDGFR740Y-PPDGFR-740Y-PY-P 740Y-P740Y-P-740