7acc1

**7acc1** is a small molecule inhibitor that specifically blocks lactate influx—but not efflux—through monocarboxylate transporters MCT1 and MCT4 in tumor cells. It acts by selectively interfering with the lactate uptake process, thereby altering metabolic dynamics in the lactate-rich tumor microenvironment. This specificity is unique compared to other MCT inhibitors, which tend to block both influx and efflux. 7acc1 has demonstrated anti-tumor activity in mouse models of cervical, colorectal, and breast cancers through delayed tumor growth and reduced relapse after chemotherapy. The compound enhances immune cell (NK cell) activity in vivo, further contributing to anti-cancer effects. Its molecular structure is 7-(diethylamino)-2-oxochromene-3-carboxylic acid, and its CAS number is 50995-74-9[1][3][4][8][5][6].

Other names

Coumarin D 14217-DCCA7-diethylamino-2-oxo-2H-chromen-3-carboxylic acid7-(diethylamino)coumarin-3-carboxylic acid