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7d

Development stage: Preclinical
Modality: Small Molecules
Administration: Intragastric

Overview

7d is a novel flavanone derivative with potential antipsychotic effects. It functions by decreasing the activity of dopamine D2 receptors and inhibiting the over-production of nitric oxide, suggesting a dual mechanism involving dopaminergic modulation and anti-neuroinflammatory properties. In preclinical studies, 7d has been shown to reverse MK-801-induced locomotor activity and decrease apomorphine-induced climbing behavior in mice, indicating its efficacy in models relevant to schizophrenia.

Targets

DRD2 (Dopamine D2 Receptor)

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