7DC2-DM1

7DC2-DM1 is an experimental antibody-drug conjugate (ADC) designed to target CD47, a cell surface protein often overexpressed in various cancers to inhibit phagocytosis by macrophages (the "don't eat me" signal). The conjugate consists of the 7DC2 monoclonal antibody linked to the cytotoxic microtubule inhibitor DM1 (mertansine) via a non-cleavable linker. By binding to CD47, 7DC2-DM1 facilitates the internalisation of the cytotoxic payload into the tumor cell, leading to cell cycle arrest and apoptosis. Preclinical research has evaluated its efficacy in lung and colorectal cancer models, demonstrating high binding affinity and significant antitumor activity. It is distinguished from related conjugates like 7DC4-DM1 by its specific binding epitope and orientation on the CD47 molecule, which may influence its cellular internalization efficiency and penetration effects.

Other names

7DC2-mertansine