7G3

7G3 is a **monoclonal antibody** that targets the **interleukin-3 receptor alpha chain (IL-3Rα, also known as CD123)**. This antibody binds specifically to the N-terminal domain of IL-3Rα/CD123, which is highly expressed on leukemia stem cells and various leukemic blasts, including those in acute myeloid leukemia (AML). The mechanism of action is primarily **immunotherapeutic**, aiming to block IL-3-mediated signaling and mark cells expressing CD123 for immune-mediated destruction. 7G3 is not a marketed drug and has largely been used as a research tool and a proof-of-concept antibody for targeting CD123 in preclinical and early clinical studies. It has also been used as the antibody backbone in various experimental antibody-drug conjugates and radioimmunotherapeutics[1][2][7].

Other names

anti-IL-3 receptor alpha chain monoclonal antibodyanti-IL3 receptor alpha chain monoclonal antibodyanti-IL 3 receptor alpha chain monoclonal antibodyanti-IL-3Rα mAb