Drug intelligence / Profile preview

7I14

Development stage
Preclinical
Lead developer
University of Toledo College of Medicine
01

Overview

7I14: sourced facts only. name: "Survivin degrader 7I14 synergizes with docetaxel in castration-resistant prostate cancer by disrupting survivin dimerization and inducing its proteasome-dependent degradation" [DOI:10.1158/1538-7445.am2025-1664]; target: "Survivin degrader 7I14 synergizes with docetaxel in castration-resistant prostate cancer by disrupting survivin dimerization and inducing its proteasome-dependent degradation" [DOI:10.1158/1538-7445.am2025-1664]; developer: "University of Toledo College of Medicine and Life Sciences, Toledo, OH." [DOI:10.1158/1538-7445.am2025-1664]; stage: "In a PC-3 xenograft model, 7I14 at 15 mg/kg administered via IP twice/week effectively suppressed tumor growth and enhanced docetaxel’s effects by degrading survivin, with no added toxicity, as assessed by body weight, white blood cell counts, and hemoglobin levels." [DOI:10.1158/1538-7445.am2025-1664]

02

Targets

BIRC5 (Survivin)

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