8-(2-chloro-3,4,5-trimethoxy-benzyl)-2-fluoro-9-pent-4-ylnyl-9h-purin-6-ylamine

8-(2-chloro–3,4,5-trimethoxy-benzyl)–2-fluoro–9-pent–4-ylnyl–9H–purin–6–ylamine is a synthetic small molecule belonging to the purine-based inhibitor class. It acts as a potent inhibitor of the molecular chaperone Heat Shock Protein 90 (Hsp90), specifically binding to its N-terminal ATP-binding domain. By inhibiting Hsp90’s ATPase activity, it disrupts the folding and stability of multiple client proteins involved in cancer cell growth and survival—including Raf‐1 kinase, CDK4 and ErbB2—leading to their degradation. This compound has been studied primarily as an experimental antineoplastic agent for its potential in cancer therapy[1][2][6].

Other names

8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-(pent-4-ylnyl)-9H-purin-6-ylaMine8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent‑4‑yn‑1‑yl‑9H‑purin‑6‑aminePU24FClPU-24FClPU 24FCl