8-azaxanthine

8-Azaxanthine is a synthetic purine analog in which the carbon at position 8 of the xanthine ring is replaced by a nitrogen atom. It belongs to the triazolopyrimidine family and has notable photophysical properties such as strong fluorescence due to excited-state proton transfer (ESPT), making it useful as a molecular probe in biochemical research[5][7]. Biologically, it acts primarily as an inhibitor of urate oxidase (urate oxidase catalyzes oxidation of uric acid to allantoin) and also inhibits adenosine receptors[5]. These activities have made it valuable for studying enzyme-ligand interactions and receptor-binding mechanisms. Additionally, it demonstrates antibacterial activity against Pseudomonas aeruginosa and Trypanosoma cruzi[5]. Its main use is experimental; there are no approved medical indications or clinical trials for therapeutic use.

Other names

XanthazolAzaxanthine2,6-dioxy-8-azapurine2,6-dihydroxy-8-azapurinensc756nsc-756nsc 756