8-chloroadenosine

8-Chloroadenosine is a synthetic chlorine-substituted analog of the purine nucleoside adenosine. It acts as an antimetabolite and ribonucleoside analog with potential antineoplastic activity. Upon administration, it is phosphorylated intracellularly to form 8-chloro-adenosine triphosphate (8-Cl-ATP), which competes with ATP during transcription and becomes incorporated into RNA. This disrupts RNA synthesis, inhibits cellular proliferation, depletes endogenous ATP pools, induces endoplasmic reticulum stress, causes cell-cycle arrest, and ultimately leads to apoptosis in malignant cells. It has demonstrated cytotoxicity against both lymphoid and myeloid malignancies in preclinical studies and is under clinical investigation for relapsed or refractory acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL)[1][2][4][7].

Other names

Adenosine, 8-chloro-8-Chloro-adenosine34408-14-5