Drug intelligence / Profile preview

8-fluorotryptanthrin

Development stage
Preclinical
Lead developer
Panjab University
01

Overview

8-fluorotryptanthrin: sourced facts only. name: "Most importantly, combination therapy of this IDO-1 inhibitor (C1) with artemether-lumefantrine led to best immunochemotherapeutic effects, with complete parasitaemia suppression and full survival along with enhanced immune restoration by D7 and D14." [PMID:41187565]; target: "Most importantly, combination therapy of this IDO-1 inhibitor (C1) with artemether-lumefantrine led to best immunochemotherapeutic effects, with complete parasitaemia suppression and full survival along with enhanced immune restoration by D7 and D14." [PMID:41187565]; developer: "Parasitology Lab, Department of Zoology, Panjab University, Chandigarh, 160014, India." [PMID:41187565]; stage: "The in vivo studies in P. berghei-infected BALB/c mice demonstrated that C1, particularly at 20 mg/kg body weight, significantly reduced parasitaemia, restored liver and kidney functions, enhanced survival, and modulated T-cell and B-cell populations." [PMID:41187565]

02

Targets

IDO1 (Indoleamine 2,3-dioxygenase 1)

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