8-methoxycoumarin-3-carboxamide

8-methoxycoumarin-3-carboxamide is a synthetic coumarin-based small molecule investigated for its potential therapeutic application in hepatocellular carcinoma (HCC). It serves as the parent scaffold for a novel series of N-(substituted-phenyl)-8-methoxycoumarin-3-carboxamides designed to target liver cancer cells. The compound demonstrates moderate antiproliferative activity against HepG2 cells, while its derivatives, such as the 5-bromo analogue (Compound 5), exhibit significantly higher potency. Its mechanism of action involves the activation of executioner caspases (Caspase-3 and Caspase-7) and the inhibition of β-tubulin polymerization. By disrupting microtubule dynamics and triggering the apoptotic pathway, the compound induces cell cycle arrest (typically in the G1/S or G2/M phases) and programmed cell death in neoplastic cells with minimal impact on normal healthy cells.

Other names

8-methoxy-2-oxo-2H-chromene-3-carboxamide