Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
8-o-acetylharpagide
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral, Subcutaneous
01
Overview
8-o-acetylharpagide (AT-1) is a natural iridoid glycoside compound purified from the endemic Taiwanese plant *Ajuga taiwanensis*. It is being investigated for its potential as a selective radiosensitizer and anti-cancer agent, particularly in the treatment of hypopharyngeal squamous cell carcinoma (HPSCC). The compound demonstrates selective cytotoxicity, significantly reducing the viability of cancer cells (such as FaDu) while exerting minimal effects on normal human periodontal ligament fibroblasts (PDL). Its mechanism of action involves the induction of G2/M phase arrest and DNA double-strand breaks, accompanied by the downregulation of pro-survival proteins such as AKT and Bcl-2, and the modulation of cell cycle regulators like Cyclin B1. Beyond oncology, 8-o-acetylharpagide has been reported to possess anti-aging and anti-inflammatory properties.
- Other names
- 8-O-acetylharpagide
02
Targets
BCL-2 (BCL-2 family)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)
Beyond the preview
Go deeper on 8-o-acetylharpagide.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on 8-o-acetylharpagide.