8-shogaol

8-shogaol is a bioactive phytochemical and pungent constituent derived from ginger (*Zingiber officinale*), specifically formed through the dehydration of 8-gingerol during storage or thermal processing. It is being investigated for its vasorelaxant properties, particularly its ability to relax pre-contracted pulmonary arteries. The compound's mechanism of action involves the inhibition of phospholipase C (PLC), a key enzyme in the constriction-relaxation pathway of smooth muscle. By inhibiting PLC, 8-shogaol attenuates endothelin-1 (ET1)-stimulated increases in intracellular calcium within pulmonary artery smooth muscle cells (PASMC). This pharmacological profile suggests potential therapeutic application in the management of vascular hypertensive disorders, including pulmonary hypertension.

Other names

[8]-shogaol1-(4-hydroxy-3-methoxyphenyl)tridec-4-en-3-one