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89Zr-16A

Development stage: Phase 1
Lead developer: ImaginAb
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

**89Zr-16A** is an investigational zirconium-89 radiolabeled 16A monoclonal-antibody immunoPET tracer for molecular imaging of tumors expressing an aberrantly glycosylated MUC1 neoantigen. The 16A antibody recognizes a GSTA glycosite-signature epitope within the MUC1 tandem-repeat region, with preferential uptake and internalization reported in COSMC-deficient MUC1-expressing tumor cells. The tracer is intended for PET/CT-based detection and characterization of MUC1-positive solid tumors, with a gastric-cancer-focused, phase-not-specified diagnostic clinical study registered as NCT06429891. ([jnm.snmjournals.org](https://jnm.snmjournals.org/content/65/supplement_2/242030))

Other names: 89 Zr-16A89Zr-16A89Zr-labeled 16A

Targets

MUC1-N (Mucin-1 subunit alpha)

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