89Zr-AMG211

89Zr-AMG211 is a radiolabeled diagnostic imaging agent consisting of the bispecific T-cell engager (BiTE) AMG 211 (also known as MEDI-565) conjugated to the positron-emitting radionuclide Zirconium-89 (89Zr). AMG 211 is a bispecific single-chain antibody construct that targets carcinoembryonic antigen (CEA) on tumor cells and the CD3 epsilon subunit of the human T-cell receptor. By labeling AMG 211 with 89Zr, researchers can use Positron Emission Tomography (PET) to non-invasively visualize and quantify the biodistribution and tumor uptake of the drug in cancer patients. This imaging approach is particularly relevant for gastrointestinal adenocarcinomas, which frequently overexpress CEA, as it helps identify patients more likely to benefit from AMG 211 therapy by assessing target engagement and tumor heterogeneity.

Other names

Zirconium-89 AMG 211Zirconium89 AMG 211Zirconium 89 AMG 211[89Zr]AMG 21189Zr-labeled AMG 211