89Zr-anti-CD4

89Zr-anti-CD4 is a preclinical zirconium-89 (89Zr)-labeled immuno-positron emission tomography (immunoPET) imaging tracer designed for the non-invasive, in vivo assessment of CD4+ T cells. The tracer is typically prepared by conjugating an anti-CD4 monoclonal antibody (such as the murine clone GK1.5) or its engineered fragments (such as cys-diabodies) with a chelator like deferoxamine (DFO) and radiolabeling it with zirconium-89. It is utilized in preclinical research to visualize and quantify CD4+ T cell infiltration and density in tumors or inflammatory tissues (such as in colitis models) and to evaluate immune responses during immunotherapy, such as PD-L1 checkpoint blockade.

Other names

89Zr-DFO-anti-CD489Zr-GK1.589Zr-GK1.5 FR cDb89Zr-GK1.5 N80D cDb89Zr-GK1.5 cDb89Zr-labeled anti-CD489Zr-labeled anti-CD4 antibodyzirconium-89-labeled anti-CD4zirconium89-labeled anti-CD4zirconium 89-labeled anti-CD4