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89Zr-DFO-B7-H3
- Development stage
- Preclinical
- Lead developer
- Beijing Tiantan Hospital
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Gamma Emitters → Radiopharmaceuticals
- Administration
- Intrathecal, Intravenous
01
Overview
89Zr-DFO-B7-H3 is a target-specific radiopharmaceutical and immuno-positron emission tomography (immuno-PET) imaging tracer. It consists of a monoclonal antibody targeting B7-H3 (CD276), conjugated to the chelator desferrioxamine (DFO) and radiolabeled with the positron-emitting radionuclide zirconium-89 (89Zr). B7-H3 is an immune checkpoint protein overexpressed in various solid tumors, including gliomas and melanoma, while showing limited expression in healthy tissues. 89Zr-DFO-B7-H3 is utilized in preclinical and clinical research to noninvasively quantify B7-H3 expression levels, select patients for B7-H3-targeted therapies (such as CAR-T cell therapy or antibody-drug conjugates), and monitor antigen modulation or escape during treatment.
- Other names
- 89Zr-B7-H389Zr-DFO-anti-B7-H3[89Zr]p-SCN-Bz-DFO-B7-H3
02
Targets
B7-H3
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